Provided herein are novel MALT1 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer and immunological diseases and processes for preparing such compounds.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403756 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.4c00390 | DOI Listing |
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MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression.
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September 2024
Department of Pediatrics, University of Pittsburgh School of Medicine; Pittsburgh, Pennsylvania.
MALT1 protease is an intracellular signaling molecule that promotes tumor progression via cancer cell-intrinsic and cancer cell-extrinsic mechanisms. MALT1 has been mostly studied in lymphocytes, and little is known about its role in tumor-associated macrophages. Here, we show that MALT1 plays a key role in glioblastoma (GBM)-associated macrophages.
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In silico study of some plant compounds as potential anticancer agents targeting MALT1 allosteric domain.
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Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria.
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- MALT1 is a crucial protein involved in immune responses, and its unusual signaling is linked to various diseases, including cancer, making it a target for new therapies.
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MALT1 Inhibitors for Treating Cancer and Immunological Diseases.
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Smith, Gambrell & Russell LLP, 1105 West Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.
Provided herein are novel MALT1 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer and immunological diseases and processes for preparing such compounds.
View Article and Find Full Text PDFBlood MALT1 serves as a potential biomarker reflecting the response and survival of immune‑checkpoint‑inhibitor therapy in advanced hepatocellular carcinoma.
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- Scientists are studying a new treatment option for a type of liver cancer called hepatocellular carcinoma (HCC) that helps boost the immune system.
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