AI Article Synopsis
- A 78-year-old woman was hospitalized due to confusion, initially diagnosed with low sodium but continued to experience symptoms even after treatment.
- After testing her cerebrospinal fluid (CSF) and imaging, she was found to have chronic meningitis, initially treated for tuberculosis without success.
- Positive PCR results led to successful treatment with antifungal medications, resulting in full recovery of her cognitive functions and highlighting the importance of considering sporotrichosis in chronic meningitis cases.
Article Abstract
A 78-year-old woman presented to hospital with altered mental status. Hyponatremia was diagnosed and treated. She maintained mental confusion despite normal sodium. No headache, fever or focal signs were present. CSF analysis showed chronic meningitis; MRI demonstrated basilar enhancement. She was empirically treated for tuberculosis, with no improvement. PCR for in the CSF was positive. After treatment with Amphotericin followed by oral itraconazole, she completely recovered her cognitive abilities. Follow-up CSF was normal. This report illustrates the need to consider sporotrichosis in the differential diagnosis of chronic meningitis in immunocompetent, and the importance of PCR as a diagnostic tool.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406475 | PMC |
| http://dx.doi.org/10.1016/j.mmcr.2024.100665 | DOI Listing |
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