AI Article Synopsis
- Type 2 diabetes mellitus (T2DM) is a global metabolic disorder linked to several health issues, including elevated insulin and glucose levels, which can drive cancer development.
- Studies suggest that the characteristics of T2DM, such as hyperinsulinemia and hyperglycemia, may enhance cancer cell behaviors, like resistance to drugs and increased growth and spread of tumors.
- The focus of the research is to understand how T2DM-related factors contribute to cancer progression and to identify potential therapeutic targets for treating cancers associated with this condition.
Article Abstract
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder affecting people worldwide. It is characterized by several key features, including hyperinsulinemia, hyperglycemia, hyperlipidemia, and dysbiosis. Epidemiologic studies have shown that T2DM is closely associated with the development and progression of cancer. T2DM-related hyperinsulinemia, hyperglycemia, and hyperlipidemia contribute to cancer progression through complex signaling pathways. These factors increase drug resistance, apoptosis resistance, and the migration, invasion, and proliferation of cancer cells. Here, we will focus on the role of hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with T2DM in cancer development. Additionally, we will elucidate the potential molecular mechanisms underlying their effects on cancer progression. We aim to identify potential therapeutic targets for T2DM-related malignancies and explore relevant directions for future investigation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405243 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1396022 | DOI Listing |
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