Umbilical endometriosis or Villar's nodule is defined as the presence of endometrial tissue within the umbilicus and represent 0.5%-1% cases of endometriosis ectopia. It is classified as primary or secondary based on the surgical history. The important symptoms that characterize primary umbilical endometriosis were cyclical pain and a palpable mass that may be associated with bleeding. These features have temporal association with catamenia. Presented is a 30 year old woman with clinical features that suggested primary umbilical endometriosis in the past 5 years. It was confirmed by histology and coexisted with uterine fibroid. In the absence of previous surgery, primary umbilical endometriosis should be considered in the differential diagnosis in females of reproductive age with umbilical pain and nodule related to catamenia. Surgery is the treatment of choice and this should be individualized as some lesions can be managed by local excision with satisfactory outcome regarding the cessation of the presenting symptoms with good cosmetic outcome.
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http://dx.doi.org/10.1177/20363613241285148 | DOI Listing |
Radiol Case Rep
February 2025
Faculty of Medicine and Pharmacy, Mohammed Ist University, Oujda, Morocco.
Int Med Case Rep J
December 2024
Gynecology and Obstetric Department, Kabul University of Medical Science, Shahr Ara University Hospital, Kabul, Afghanistan.
Primary umbilical endometriosis is a rare condition in which there is endometrial glands and stroma in the umbilicus. Primary umbilical endometriosis is also called villar's nodule. This condition is a diagnostic challenge, the pathophysiology of the disease is not well defined and should be considered in all other pathologies of the umbilicus.
View Article and Find Full Text PDFRare Tumors
September 2024
Department of Surgery, University of Calabar/University of Calabar Teaching Hospital, Calabar, Nigeria.
Proc Natl Acad Sci U S A
September 2024
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom.
Endometriosis negatively impacts the health-related quality of life of 190 million women worldwide. Novel advances in nonhormonal treatments for this debilitating condition are desperately needed. Macrophages play a vital role in the pathophysiology of endometriosis and represent a promising therapeutic target.
View Article and Find Full Text PDFJ Mol Med (Berl)
November 2024
Department of Gynaecology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Endometriosis is a multifactorial gynecological disease, with angiogenesis as a key hallmark. The role of exosomal microRNAs (miRNAs) in endometriosis is not well understood. This study investigates differentially expressed exosomal miRNAs linked to angiogenesis in endometriosis, clarifies their molecular mechanisms, and identifies potential targets.
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