AI Article Synopsis
- Magnesium imbalances are common in septic patients, but the link between serum magnesium levels and mortality is still unclear.
- This study analyzed data from over 10,000 patients in the U.S. and China to explore the relationship between magnesium levels and 28-day mortality rates in septic patients.
- Results showed that higher serum magnesium levels correlated with an increased risk of mortality, suggesting that monitoring magnesium levels could help identify septic patients at greater risk of death.
Article Abstract
Magnesium imbalances commonly exist in septic patients. However, the association of serum magnesium levels with mortality in septic patients remains uncertain. Herein, we elucidated the association between serum magnesium and all-cause mortality in septic patients from American and Chinese cohorts by analyzing data from 9099 patients in the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and 1727 patients from a university-affiliated hospital' intensive care unit in China. Patients in both cohorts were categorized into five groups based on serum magnesium quintiles from the MIMIC-IV dataset. Patients with higher serum magnesium levels exhibited an increased risk of 28-day mortality in both cohorts. The restricted cubic spline (RCS) curves revealed a progressively elevated risk of 28-day mortality with increasing serum magnesium in MIMIC-IV cohort, while a J-shaped correlation was observed in institutional cohort. Our findings have validated the association between high serum magnesium and high mortality in sepsis across different races and medical conditions. Serum magnesium levels might be useful in identifying septic patients at higher mortality risk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406045 | PMC |
| http://dx.doi.org/10.1002/mco2.713 | DOI Listing |
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