AI Article Synopsis
- Recent advancements in DNA and RNA bioengineering have led to the creation of stimuli-responsive nanostructures that can react dynamically to various biological and physical triggers.
- These innovative nanostructures are highly sensitive and specific, making them suitable for critical applications like biomarker detection, gene therapy, and precise drug delivery.
- The review discusses the bioengineering techniques for creating these nanostructures, their potential uses in structural biology and biomedicine, and the challenges and opportunities for future development.
Article Abstract
Recent advancements in DNA and RNA bioengineering have paved the way for developing stimuli-responsive nanostructures with remarkable potential across various applications. These nanostructures, crafted through sophisticated bioengineering techniques, can dynamically and precisely respond to both physiological and physical stimuli, including nucleic acids (DNA/RNA), adenosine triphosphate, proteins, ions, small molecules, pH, light, and temperature. They offer high sensitivity and specificity, making them ideal for applications such as biomarker detection, gene therapy, and controlled targeted drug delivery. In this review, we summarize the bioengineering methods used to assemble versatile stimuli-responsive DNA/RNA nanostructures and discuss their emerging applications in structural biology and biomedicine, including biosensing, targeted drug delivery, and therapeutics. Finally, we highlight the challenges and opportunities in the rational design of these intelligent bioengineered nanostructures.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407293 | PMC |
| http://dx.doi.org/10.34133/bmef.0050 | DOI Listing |
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