AI Article Synopsis
- The study examined unexpected subclinical spikes (USCS) in pediatric patients with high-density EEGs, finding that 18.5% of the tests were abnormal, with large portions displaying USCS.
- There was a strong link between USCS, attention deficits, executive dysfunction, and a higher likelihood of ADHD, along with abnormal MRI findings in 32.6% of those with USCS.
- The USCS group performed worse on various intelligence and memory tests compared to the average population, suggesting that USCS could serve as important biomarkers for improving clinical treatment and understanding brain functions.
Article Abstract
This study aimed to analyze the frequency of unexpected subclinical spikes (USCS) in pediatric patients who underwent high-density electroencephalogram (HD-EEG). Of the 4481 successful HD-EEG studies, 18.5% (829) were abnormal, and 49.7% of these abnormal studies showed SCS, of which 64.1% were USCS. USCS were found to be correlated with attention/concentration deficits and executive dysfunction, often accompanied by the dual psychiatric diagnosis of ADHD. MRI revealed abnormal findings in 32.6% of the subjects with USCS, such as abnormal signal or signal hyperintensity in brain parenchyma, temporal or arachnoid cysts, and vascular malformations. Moreover, the USCS group who received neuropsychiatric testing scored lower than the population mean on Full-Scale Intelligence Quotient, Working Memory Index, and Processing Speed Index. This study highlights the potential of USCS as biomarkers that can lead to changes in clinical management and outcomes, provide valuable information about pathophysiological mechanisms, and suggest potential treatment pathways.
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| http://dx.doi.org/10.1177/15500594241284090 | DOI Listing |
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Article Synopsis
- The study examined unexpected subclinical spikes (USCS) in pediatric patients with high-density EEGs, finding that 18.5% of the tests were abnormal, with large portions displaying USCS.
- There was a strong link between USCS, attention deficits, executive dysfunction, and a higher likelihood of ADHD, along with abnormal MRI findings in 32.6% of those with USCS.
- The USCS group performed worse on various intelligence and memory tests compared to the average population, suggesting that USCS could serve as important biomarkers for improving clinical treatment and understanding brain functions.
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