AI Article Synopsis
- The study aimed to analyze the microbiome across different mucosal organs (oral, gut, urinary tract, and vaginal) in patients with cervical cancer.
- Results indicated that cervical cancer patients showed lower diversity in their oral and gut microbiota, while their vaginal microbiota demonstrated higher diversity; significant differences in the composition of microbiota were found between cases and control groups.
- The research found specific bacterial groups enriched in the oral and urinary microbiota of cervical cancer patients, suggesting a connection between microbiome alterations and the presence of the disease.
Article Abstract
Objectives: The aim of this study was to characterize the microbiome of multiple mucosal organs in cervical cancer (CC) patients.
Methods: We collected oral, gut, urinary tract, and vaginal samples from enrolled study participants, as well as tumor tissue from CC patients. The microbiota of different mucosal organs was identified by 16S rDNA sequencing and correlated with clinical-pathological characteristics of cervical cancer cases.
Results: Compared with controls, CC patients had reduced α-diversity of oral and gut microbiota (p < 0.001, p = 0.049, p = 0.013 p = 0.030), although there was an opposite trend in the vaginal microbiota (p = 0.028, p = 0.006). There were also significant differences in the β-diversity of the microbiota at each site between cases and controls (p = 0.002, p = 0.037, p = 0.001, p = 0.001). The uniformity of urine microbiota was lower in patients with cervical squamous cell carcinoma (p = 0.036) and lymph node metastasis (p = 0.027, p = 0.028, p = 0.021, p = 0.047). The composition of bacteria in urine also varied among patients with different ages (p = 0.002), tumor stages (p = 0.001) and lymph node metastasis (p = 0.002). In CC cases, Pseudomonas were significantly enriched in the oral, gut, and urinary tract samples. In addition, Gardnerella, Anaerococcus, and Prevotella were biomarkers of urinary tract microbiota; Abiotrophia and Lautropia were obviously enriched in the oral microbiota. The microbiota of tumor tissue correlated with other mucosal organs (except the gut), with a shift in the microflora between mucosal organs and tumors.
Conclusions: Our study not only revealed differences in the composition and diversity of the vaginal and gut microflora between CC cases and controls, but also showed dysbiosis of the oral cavity and urethra in cervical cancer cases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409810 | PMC |
| http://dx.doi.org/10.1186/s12885-024-12915-1 | DOI Listing |
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