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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518974 | PMC |
| http://dx.doi.org/10.1038/s41375-024-02412-6 | DOI Listing |
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Fracture-related infection (FRI) is a serious complication that occurs primarily in surgically treated fractures. FRIs occur when bacteria enter the site of bony injury and alter the healing inflammatory response within the bone. This can prevent bone regeneration and can lead to long-lasting complications such as chronic infection, pain, nonunion, and amputation.
View Article and Find Full Text PDFA framework for sequential monitoring of individual N-of-1 trials and combining results across a series of sequentially monitored N-of-1 trials.
Clin Trials
January 2025
Department of Biostatistics, University of Washington, Seattle, WA, USA.
Background: N-of-1 trials compare two or more treatment options for a single participant. These trials have been used to study options for chronic conditions such as arthritis and attention deficit hyperactivity disorder. In addition, they have been suggested as a means to study interventions in rare populations that may not be tractable to include in standard clinical trials, such as treatment options for HIV-positive patients in need of organ transplant.
View Article and Find Full Text PDFEffects of a plantar fascia stretching on ankle passive range of motion, balance, gait, and ankle stability in patients with chronic stroke: a randomized controlled study.
Top Stroke Rehabil
January 2025
Department of Physical Therapy, Graduate School, Kyungnam University, Changwon, Republic of Korea.
Objectives: The plantar fascia stretching intervention can correct balance ability and induces a change spatiotemporal parameter doing gait ability. Our objective is to compare the effects of a 4-week program of plantar fascia stretching with those of calf stretching exercise on ankle dorsiflexion passive range of motion (DF-PROM), open and closed eyes static balance ability, gait parameters, and foot and ankle disability index in chronic post-stroke condition.
Methods: Participants were randomized to either the plantar fascia stretching ( = 10) or calf stretching ( = 10) group.
Does birth weight or preterm birth predict worse pain prognosis in adulthood? A Northern Finland Birth Cohort Study followed up to 46 years of age.
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December 2024
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China; Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Although pain is a highly common symptom, only a subset of individuals develops chronic and disabling conditions. Delving into the predictors for poor musculoskeletal pain (MSK) outcomes in adulthood may help identify those needing early prevention and intervention. This study aimed to evaluate whether birth weight or preterm birth predicts worse prognosis of MSK pain in adulthood.
View Article and Find Full Text PDFThe interplay of gut microbiota and heavy metals in Multiple Sclerosis patients.
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Department of Biology, Faculty of Science, Arak University, Arak, 38156-8-8349, Iran.
Article Synopsis
- Multiple Sclerosis (MS) patients show significantly higher concentrations of heavy metals like arsenic, nickel, manganese, and zinc in their stool compared to healthy individuals, while levels of iron, lead, titanium, and tin are notably lower.
- The study also reveals alterations in the gut microbiome of MS patients, with increased abundance of certain bacterial families indicative of potential changes associated with the disease.
- The research highlights a novel approach by combining heavy metal measurement and gut microbiome analysis, suggesting new insights into the disease's pathogenesis and possible therapeutic strategies.
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