Experiencing highly stressful events can have detrimental and lasting effects on brain morphology. The current study explores the effects of stress during childhood and adulthood on grey matter macro- and microstructure using a sub-sample of 720 participants from the UK Biobank with very high or very low childhood and adulthood stress scores. We used T1-weighted and diffusion MRI data to assess grey matter macro- and microstructure within bilateral hippocampus, amygdala and thalamus. Findings showed that childhood stress is associated with changes in microstructural measures bilaterally within the hippocampus and amygdala. No effects of adulthood stress on brain microstructure were found. No interaction effects between sex and stress (either childhood or adulthood) were observed for any brain imaging measure. Analysis of sub-segments of the hippocampus showed that childhood stress predominantly impacted the bilateral heads of the hippocampus. Overall, these findings suggest that highly stressful experiences during childhood, but not adulthood, have lasting impact on brain microstructure. The effects of these experiences in childhood appear to persist regardless of experiences of high or low stress in adulthood.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11408494 | PMC |
| http://dx.doi.org/10.1038/s41598-024-71965-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictive factors of health related quality of life in children and adolescents with celiac disease: An Italian multicenter study on behalf of the SIGENP.
Dig Liver Dis
January 2025
Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, 00166 Rome, Italy; Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy.
Background: In pediatric patients, celiac disease (CD) may influence the health-related quality of life (HRQoL).
Aims: The study aimed to assess HRQoL and further characterise the clinical factors associated with reduced HRQoL, in a large multicenter pediatric cohort with CD.
Methods: The disease-specific questionnaire CD Dutch Questionnaire (CDDUX) and the generic questionnaire Paediatric Quality of Life Inventory (PedsQL) were used to assess the HRQoL.
Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study.
J Obes Metab Syndr
January 2025
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Whether there is a causal relationship between childhood obesity and increased risk of chronic kidney disease (CKD) remains controversial. This study sought to explore how body size in childhood and adulthood independently affects CKD risk in later life using a Mendelian randomization (MR) approach.
Methods: Univariate and multivariate MR was used to estimate total and independent effects of body size exposures.
Development of the relationship between visual selective attention and auditory change detection.
Neuroimage
January 2025
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. Electronic address:
Understanding the developmental trajectories of the auditory and visual systems is crucial to elucidate cognitive maturation and its associated relationships, which are essential for effectively navigating dynamic environments. Our one recent study has shown a positive correlation between the event-related potential (ERP) amplitudes associated with visual selective attention (posterior contralateral N2) and auditory change detection (mismatch negativity) in adults, suggesting an intimate relationship and potential shared mechanism between visual selective attention and auditory change detection. However, the evolution of these processes and their relationship over time remains unclear.
View Article and Find Full Text PDFFear extinction retention in children, adolescents, and adults.
Dev Cogn Neurosci
January 2025
Department of Medical Sciences, Experimental Cognitive and Affective Neuroscience Lab, Uppsala University, Uppsala, Sweden. Electronic address:
Past results suggest that fear extinction and the return of extinguished fear are compromised in adolescents. However, findings have been inconclusive as there is a lack of fear extinction and extinction retention studies including children, adolescents and adults. In the present study, 36 children (6-9 years), 40 adolescents (13-17 years) and 44 adults (30-40 years), underwent a two-day fear conditioning task.
View Article and Find Full Text PDFChildhood residential and neighbourhood mobility: Consequences for educational attainment in young adulthood.
Adv Life Course Res
January 2025
Department of Human Geography, Stockholm University, Sweden.
Research on the consequences of residential mobility for educational outcomes is inconclusive about when and for whom moving is detrimental or beneficial. Whether moving during childhood impacts educational attainment depends on how often, how far and at which age one moves; and on whether the neighbourhood conditions improve or decline with the move. This study aims to better understand under which circumstances moving during childhood impacts educational attainment by studying residential mobility and neighbourhood trajectories of children born in different types of neighbourhoods and how this is associated with completion of tertiary education.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!