AI Article Synopsis
- Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer commonly seen in older adults and tends to develop in sun-exposed areas.
- The article presents two cases: a 91-year-old woman with a brown nodule on her temple and a 76-year-old man with a growing nodule on his buttock, both diagnosed with MCC.
- The study highlights the importance of testing for Merkel cell polyomavirus (MCPyV) at diagnosis to determine prognosis, as genetic mutations and outcomes differ significantly between virus-associated and non-virus-associated MCC.
Article Abstract
Merkel cell carcinoma (MCC) is known as a rare and highly malignant neuroendocrine skin cancer and often occurs in the sun-exposed parts of the elderly individuals. In this article, we reported 2 cases of MCC and reviewed relative literature. Case 1 was a 91-year-old woman who presented with a half-year history of a brown nodule on the left temple. The histopathological and immunohistochemistry examination diagnosis was MCC with negative staining of Merkel cell polyomavirus large T antigen (CM2B4). Case 2 was a 76-year-old man with a nodule on his right buttock that gradually increased from approximately 3 mm to 1.5 cm in diameter in 1 month without pain. The biopsy diagnosis was MCC with positive staining of CM2B4. Previous studies have found that the genetic mutation and prognosis of polyomavirus-associated MCC (MCCP) and nonviral MCC (MCCN) are significantly different. Large T antigen plays a crucial role in Merkel cell polyomavirus (MCPyV) oncogenesis. Testing for the MCPyV at the onset of MCC is recommended, which is helpful in predicting the prognosis of patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486931 | PMC |
| http://dx.doi.org/10.1097/DAD.0000000000002837 | DOI Listing |
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