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Classic and Immunoblastoid Variants of Blastic Plasmacytoid Dendritic Cell Neoplasm.
Am J Dermatopathol
December 2024
Hematology Unit, Dubai Hospital, Dubai, United Arab Emirates.
Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response.
Leukemia
December 2018
Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Article Synopsis
- Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive skin-related blood cancer with unclear causes and a generally poor outlook for patients.
- In a study of 118 BPDCN cases, researchers found different cell types based on morphology and noted significant associations between certain characteristics and genetic markers, including MYC rearrangement and expression.
- Treatment strategies could be improved by using inhibitors like BCL2, as they were effective in both major cell lines studied, while treatments targeting MYC showed variability in effectiveness, pointing towards a need for personalized medicine approaches.
Expression of interleukin-6 in Castleman's disease.
Hum Pathol
August 1993
Department of Pathology, University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, Little Rock.
Although mixed forms of Castleman's disease (CD) may occur, two classically recognized forms are the angiofollicular (hyaline vascular [V]) variant and the plasma cell (P) variant. The two forms of CD differ greatly in their clinical and histopathologic manifestations. Plasma cell CD is characterized by the presence of hyperplastic germinal centers (GCs) and sheets of plasma cells in the interfollicular areas.
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