AI Article Synopsis
- The study looked at how effective clozapine is for treating tardive syndromes, which are problems that can happen after taking certain medications for a long time.
- Most of the patients in the study had issues like muscle spasms or uncontrolled movements when they started using clozapine.
- After treatment, many patients saw a big improvement, with some having their symptoms completely go away!
Article Abstract
Aim: This retrospective study aimed to evaluate the long-term effectiveness of switching to clozapine in the management of tardive syndromes (TS).
Methodology: The treatment records of patients who had TS at the time of starting clozapine, were reviewed and demographic and clinical data was extracted on a predesigned performa.
Results: About three-fourth (74.2 %) of the study subjects had tardive dystonias and two-third (69.7 %) had tardive dyskinesia at the time of starting clozapine. About half (48.5 %) of the patients had both tardive dystonia and dyskinesia. A small proportion (13.6 %) also had tardive akathisia at the time of starting clozapine. About three-fourth (72.2 %) of the patients had >50 % reduction, and about two-third (66.6 %) of the patients had >75 % reduction and nearly half (54.5 %) of the patients had complete resolution of dyskinesia at the last follow-up. Similar trends were seen in reduction in dystonia, i.e., >50 % reduction in 74.3 %, >75 % reduction in 62.2 % and complete resolution was seen in 56.1 %.
Conclusions: The present study suggest that clozapine is useful in the management of drug induced tardive dyskinesia and tardive dystonia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ajp.2024.104245 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!