AI Article Synopsis
- Deoxynojirimycin (DNJ) is a valuable α-glucosidase inhibitor, but its practical use has been limited due to complex and expensive extraction processes.
- This study developed a simpler method to enrich DNJ from Morus alba L. using cation exchange resins, specifically LSI and D113, which showed effective adsorption and desorption capabilities.
- The research confirmed that the dual resin method could enhance DNJ purity to 44% while achieving a recovery rate of 78%, indicating a viable approach for industrial applications.
Article Abstract
Deoxynojirimycin (DNJ) is an α-glucosidase inhibitor with high food values. However, the complex and costly enrichment processes have greatly prevented its application. Herein, this study aimed to propose a simple and efficient enrichment process for DNJ from Morus alba L. extracts using cation exchange resins. The LSI and D113 resins were chosen due to their excellent adsorption and desorption properties. The adsorption characteristics agreed with the pseudo-first-order kinetic model and the Langmuir isotherm model. This adsorption was chemisorption, spontaneous, endothermic and entropy-driven. Furthermore, the concentration and pH of the extracts, desorption solvent, breakthrough and elution curves, sample loading and elution rate were investigated to optimize the enrichment process by resin column chromatography. The results also showed that the purity of DNJ was improved to 44.00 % with a total recovery of 78.21 % using the LSI-D113 combination strategy. This research demonstrated the industrial feasibility of DNJ enrichment using cation exchange resins.
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| http://dx.doi.org/10.1016/j.foodchem.2024.141281 | DOI Listing |
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