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Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways.
Front Pharmacol
January 2025
Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.
Introduction: Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a powerful inducer of systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses and septic disorders. Recent research indicates that oxytocin (OXY), a neuropeptide typically linked to social bonding and reproductive functions, may influence inflammatory processes. This work examines the impact of OXY on LPS-induced testicular damage, aiming to elucidate its therapeutic potential in addressing inflammatory disorders and broadening the comprehension of its functions beyond conventional neuroendocrine roles.
View Article and Find Full Text PDFParental Monitoring, Deviant Peer Affiliation, and Adolescents' Cyberbullying Involvement: Prospective Within-Person Associations.
J Youth Adolesc
January 2025
Department of Psychology, Renmin University of China, Beijing, China.
Cybervictimization and cyberbullying are serious public health issues. Parental monitoring serves as a protective factor, reducing adolescents' risk of cybervictimization and cyberbullying. However, no study has systematically explored the interplay between parental monitoring, cybervictimization and cyberbullying at within-person processes, the mediating mechanisms between them, and the moderator of sex among Chinese adolescents.
View Article and Find Full Text PDFLongitudinal evolution of the transdiagnostic prodrome to severe mental disorders: a dynamic temporal network analysis informed by natural language processing and electronic health records.
Mol Psychiatry
January 2025
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Modelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time. Temporal network analysis can detect causal dependence between and within prodromal features by representing prodromal features as nodes, with their connections (edges) indicating the likelihood of one feature preceding the other. In SMD, node centrality could reveal insights into important prodromal features and potential intervention targets.
View Article and Find Full Text PDFA scoping review to examine health care professionals' experiences as family caregivers.
PLoS One
January 2025
Department of Occupational Science & Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Background: Health and social care systems must confront the challenge of supporting a growing elderly population and their caregivers. Family caregivers who are healthcare professionals are part of this context, but their caregiving experiences remain unclear.
Objective: This scoping review explored the experiences of healthcare professionals who are also family caregivers for older adults.
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