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Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature. | LitMetric

Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature.

Curr Obes Rep

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.

Published: December 2024

AI Article Synopsis

  • This review examines how mitochondrial biomarkers relate to obesity characteristics like body mass index and body composition.
  • Mitochondria are essential for energy production, and their dysfunction is linked to obesity, yet research on this connection in humans is limited.
  • The paper highlights the impact of oxidative stress and mitochondrial DNA changes linked to obesity and looks at how diet and surgery can help restore mitochondrial function, while identifying areas needing further research.

Article Abstract

Purpose Of Review: This narrative review summarizes current literature on the relationship of mitochondrial biomarkers with obesity-related characteristics, including body mass index and body composition.

Recent Findings: Mitochondria, as cellular powerhouses, play a pivotal role in energy production and the regulation of metabolic process. Altered mitochondrial functions contribute to obesity, yet evidence of the intricate relationship between mitochondrial dynamics and obesity-related outcomes in human population studies is scarce and warrants further attention. We discuss emerging evidence linking obesity and related health outcomes to impaired oxidative phosphorylation pathways, oxidative stress and mtDNA variants, copy number and methylation, all hallmark of suboptimal mitochondrial function. We also explore the influence of dietary interventions and metabolic and bariatric surgery procedures on restoring mitochondrial attributes of individuals with obesity. Finally, we report on the potential knowledge gaps in the mitochondrial dynamics for human health for future study.

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Source
http://dx.doi.org/10.1007/s13679-024-00588-7DOI Listing

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