The tandem nucleophilic addition-cyclization reaction of -alkynylpyridinecarbaldehyde with dialkyl phosphites took place very smoothly in the presence of AgNO under base conditions in DCE at 50 °C. In all cases, the reaction proceeded in a regioselective manner leading to the 5-- phosphonylated pyrido-dihydrofurans in moderate to good yields.
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| http://dx.doi.org/10.1021/acs.joc.4c00877 | DOI Listing |
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