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Follistatin controls the number of murine teeth by limiting TGF-β signaling. | LitMetric

Follistatin controls the number of murine teeth by limiting TGF-β signaling.

iScience

College of Life and Environmental Sciences, Zhejiang Key Laboratory of Organ Development and Regeneration, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

Published: September 2024

AI Article Synopsis

  • * Scientists discovered that knocking out a gene that inhibits the TGF-β signaling pathway led to extra upper incisor teeth in mice, along with noticeable changes in dental tissue development.
  • * The study found that the enhanced TGF-β signaling results in increased cell growth in the teeth and suggests that the gene involved plays a crucial role in regulating tooth number by limiting this signaling pathway.

Article Abstract

Supernumerary teeth are common developmental anomalies of dentition. However, the factors and mechanisms driving their formation remain largely unknown. Here, we report that conditional knockout of , encoding an antagonist for the transforming growth factor β (TGF-β) signaling pathway, in both oral epithelium and mesenchyme of mice ( ) led to supernumerary upper incisor teeth, arising from the lingual dental epithelium of the native teeth and preceded by an enlarged and split lingual cervical loop. deficiency greatly activated TGF-β signaling in developing maxillary incisor teeth, associated with increased epithelium cell proliferation. Moreover, teeth exhibited increased expression of , , and , which were identified as direct targets of TGF-β/SMAD2 signaling. Finally, we show that upregulation of in response to -deficiency was largely responsible for the formation of extra teeth in mice. Taken together, our investigation indicates a novel role for in controlling murine tooth number by restricting TGF-β signaling.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403059PMC
http://dx.doi.org/10.1016/j.isci.2024.110785DOI Listing

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