AI Article Synopsis
- The study aimed to compare a new MRI technique (3D UTE PREFUL) for measuring lung ventilation to existing methods (Xe-MRI and 2D multi-slice PREFUL MRI) in children with cystic fibrosis.
- Twelve pediatric CF patients underwent various MRI scans to create regional ventilation maps, and multiple statistical methods were used to compare the ventilation defect percentages (VDP) derived from these scans.
- Results indicated that the 3D UTE PREFUL MRI correlated well with the other methods in measuring global lung VDP, suggesting it could be a more sensitive and accessible option for assessing lung ventilation in pediatric CF patients.
Article Abstract
Purpose: To compare phase-resolved functional lung (PREFUL) regional ventilation derived from a free breathing 3D UTE radial MRI acquisition to hyperpolarized Xe-MRI (Xe-MRI), conventional 2D multi-slice PREFUL MRI, and pulmonary function tests in pediatric cystic fibrosis (CF) lung disease.
Methods: Free-breathing 3D UTE and 2D multi-slice H MRI as well as Xe-MRI were acquired in 12 stable pediatric CF patients. Using PREFUL, regional ventilation (RVent) maps were calculated from the free-breathing data. Ventilation defect percentage (VDP) was determined from 3D and 2D RVent maps (2D VDP and 3D VDP, respectively) and Xe-MRI ventilation (VDP). VDP was calculated for the whole lung and for eight regions based on left/right, anterior/posterior, and superior/inferior divisions of the lung. Global and regional VDP was compared between the three methods using Bland-Altman analysis, linear mixed model-based correlation, and one-way analysis of variance and multiple comparisons tests.
Results: Global 3D VDP, VDP, and 2D VDP were all strongly correlated (all R > 0.62, p < 0.0001) and showed minimal, non-significant bias (all <2%, p > 0.05). Three dimensional and 2D VDP significantly correlated to VDP in most of the separate lung regions (R = 0.18-0.74, p < 0.04), but showed lower inter-agreement. The superior/anterior lung regions showed the least agreement between all three methods (all p > 0.12).
Conclusion: Absolute VDP assessed by 3D UTE PREFUL MRI showed good global agreement with Xe-MRI and 2D multi-slice PREFUL MRI in pediatric CF lung disease. Therefore, 3D UTE PREFUL MRI offers a sensitive and potentially more accessible alternative to Xe-MRI for regional volumetric evaluation of ventilation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604841 | PMC |
| http://dx.doi.org/10.1002/mrm.30299 | DOI Listing |
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