AI Article Synopsis
- The medial temporal lobe (MTL), thought to be relatively unaffected in early-onset Alzheimer's disease (EOAD), was examined in detail to understand atrophy patterns among different age groups of Alzheimer's patients.
- The study included participants with memory issues and abnormal brain scans, comparing 41 EOAD individuals under 65 years old with 154 late-onset Alzheimer's (aLOAD) patients aged 70 or older, alongside cognitively healthy controls.
- Findings revealed that both EOAD and aLOAD groups had smaller MTL regions compared to controls, with specific differences in brain structure and pathology but no significant differences in tau pathology levels between the two Alzheimer's groups.
Article Abstract
Background: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking.
Methods: BioFINDER-2 participants with memory impairment, abnormal amyloid-β and tau-PET were included. Forty-one amnestic EOAD individuals ≤65 years and, as comparison, late-onset AD (aLOAD, ≥70 years, n = 154) and amyloid-β-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.
Results: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups: aLOAD showed thinner entorhinal cortices than aEOAD; aEOAD showed thinner parietal regions than aLOAD. aEOAD showed lower white matter hyperintensities than aLOAD. No differences in MTL tau-PET or transactive response DNA binding protein 43-proxy positivity were found.
Conclusions: We found evidence for MTL atrophy in amnestic EOAD and overall similar levels to aLOAD of MTL tau pathology and co-pathologies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403779 | PMC |
| http://dx.doi.org/10.1186/s13195-024-01571-z | DOI Listing |
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