Periodontal disease, one of the most prevalent diseases worldwide, is a chronic inflammatory disease caused by dysbiotic dental biofilms that trigger the host's immune response. Periodontitis is a type of periodontal disease characterized by the destruction of tissues that support the teeth. The disease is influenced by various systemic and environmental risk factors. As heavy metals have been associated with the development of chronic inflammatory diseases, the present scoping review aimed to determine the coverage of the literature on whether human contamination by heavy metals affects periodontitis, as well as their mechanisms of action. Eight studies were selected, and two reviewers evaluated them. Most studies were cross-sectional studies involving humans and one study was performed on rats. Our review revealed a significant correlation between periodontitis and bioaccumulation of lead and cadmium. Oxidative stress generated by trace metals, characterized by elevated levels of reactive oxygen species, causes tissue damage through lipid peroxidation, enzymatic oxidation, and stimulation of proinflammatory cytokines. In conclusion, heavy metals contamination may be a risk factor for the development of periodontitis. Oxidative stress factors seem to increase the extent of the inflammatory response.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12011-024-04357-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Potential Health Risks from Heavy Metal in Green Mussels (Perna Viridis) From the Southeastern Part of the Bay of Bengal.
Biol Trace Elem Res
January 2025
Department of Fisheries, Faculty of Marine Sciences and Fisheries, University of Chittagong, Chittagong, 4331, Bangladesh.
The Southeastern part of the Bay of Bengal is increasingly threatened by heavy metal pollution, posing significant risks to both aquatic life and human health. In this context, the contamination levels of six heavy metals-Cadmium (Cd), Lead (Pb), Zinc (Zn), Copper (Cu), Manganese (Mn), and Iron (Fe)-were assessed in the soft tissues of Green mussels (Perna viridis) from five key sites: Matamuhuri, Moheshkhali, Bakhkhali, Naf, and St. Martin.
View Article and Find Full Text PDFAbsence of biofilm adhesin proteins changes surface attachment and cell strategy for Hildenborough.
J Bacteriol
December 2024
School of Biological Sciences, University of Oklahoma, Norman, Oklahoma, USA.
Unlabelled: Ubiquitous in nature, biofilms provide stability in a fluctuating environment and provide protection from stressors. Biofilms formed in industrial processes are exceedingly problematic and costly. While biofilms of sulfate-reducing bacteria in the environment are often beneficial because of their capacity to remove toxic metals from water, in industrial pipelines, these biofilms cause a major economic impact due to their involvement in metal and concrete corrosion.
View Article and Find Full Text PDFCombined application of rhizobacteria, organic and inorganic amendments reduce lead and cadmium uptake and improve growth of chickpea by modulating physiology and antioxidant status.
Int J Phytoremediation
January 2025
Institute of Soil & Environmental Sciences, University of Agriculture, Pakistan.
Due to a lack of high-quality water, farmers have been compelled to use sewage water for irrigation, contaminating agricultural soils with multiple heavy metals. For the remediation of contaminated soil, plant growth-promoting rhizobacteria (PGPR), pressmud (PM), and iron (III) oxide were used to improve the growth and phytostabilization potential of chickpea grown in contaminated soil. Contaminated soil was collected from a nearby field, receiving sewage and factory water over the last 60 years.
View Article and Find Full Text PDFMRI guided copper deprivator activated immune responses and suppressed angiogenesis for enhanced antitumor immunotherapy.
Theranostics
January 2025
School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China.
Copper plays an important role in the regulation of PD-L1, suggesting that reducing copper levels within tumors may enhance anti-cancer immunotherapy. Tumor microenvironment responsive copper nanodeprivator (TMECN) was developed for enhancing immunotherapy of tumor via the cross-link of mercaptopolyglycol bipyridine and dimercaptosuccinic acid modifying FePt nanoalloy using the disulfide bond. Upon entering tumor cells, the disulfide bond in TMECN is cleaved by the overexpressed glutathione, exposing abundance of sulfhydryl groups.
View Article and Find Full Text PDFComparative analyses of persistence traits in O157:H7 strains belonging to different clades including REPEXH01 and REPEXH02 strains.
Front Microbiol
December 2024
Meat Safety and Quality Research Unit, U.S. Department of Agriculture, U.S. Meat Animal Research Center, Clay Center, NE, United States.
Recent application of whole genome sequencing in the investigation of foodborne illness outbreaks has facilitated the identification of Reoccurring, Emerging, or Persistent (REP) bacterial strains that have caused illnesses over extended periods of time. Here, the complete genomes of two O157:H7 (EcO157) outbreak strains belonging to REPEXH01 and REPEXH02, respectively, were sequenced and annotated. Comparative genomics and phenotypic analyses were carried out to identify REP-associated traits.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!