AI Article Synopsis
- Human papillomaviruses (HPVs) and herpesviruses have been found in patients with epithelial ovarian cancer (EOC), warranting a study on their prevalence in specific tissue samples.
- In a study of 97 EOC patients, HPV16 DNA was found in one-third of fallopian tube and tumor samples, with higher detection rates in high-grade serous ovarian carcinoma (HGSOC) cases.
- Additionally, cytomegalovirus (CMV) and Epstein-Barr virus (EBV) were detected in about 14% of EOC samples, indicating that HPV16 could be a potential risk factor for developing EOC.
Article Abstract
Human papillomaviruses (HPVs) and herpesviruses are detected in patients with epithelial ovarian cancer (EOC). We sought to analyze the prevalence of HPV's 16 and 18, cytomegalovirus (CMV), and Epstein-Barr virus (EBV) DNA in peripheral blood, ovarian, and fallopian tube (FT) tissue samples collected from 97 EOC patients, including 71 cases of high-grade serous ovarian carcinoma (HGSOC), and from 60 women with other tumors or non-neoplastic gynecological diseases. DNA isolates were analyzed by PCR methods, including droplet digital PCR. The results demonstrate that (1) HPV16 DNA has been detected in one-third of the FT and tumor samples from EOCs; (2) the prevalence and quantity of HPV16 DNA were significantly higher in FT samples from HGSOCs, non-HGSOCs, and ovarian metastases than in those from non-neoplastic diseases; (3) CMV and EBV have been detected in approximately one-seventh of EOC samples. The results suggest that HPV16 might be a potential risk factor for EOC development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405690 | PMC |
| http://dx.doi.org/10.1038/s41598-024-72814-0 | DOI Listing |
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