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| http://dx.doi.org/10.1371/journal.pdig.0000599 | DOI Listing |
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Flexible progestin-primed ovarian stimulation versus a GnRH antagonist protocol in predicted suboptimal responders undergoing freeze-all cycles: a randomized non-inferiority trial.
Hum Reprod
December 2024
Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.
Study Question: Are live birth rates (LBRs) per woman following flexible progestin-primed ovarian stimulation (fPPOS) treatment non-inferior to LBRs per woman following the conventional GnRH-antagonist protocol in expected suboptimal responders undergoing freeze-all cycles in assisted reproduction treatment?
Summary Answer: In women expected to have a suboptimal response, the 12-month likelihood of live birth with the fPPOS treatment did not achieve the non-inferiority criteria when compared to the standard GnRH antagonist protocol for IVF/ICSI treatment with a freeze-all strategy.
What Is Known Already: The standard PPOS protocol is effective for ovarian stimulation, where medroxyprogesterone acetate (MPA) is conventionally administered in the early follicular phase for ovulatory suppression. Recent retrospective cohort studies on donor cycles have shown the potential to prevent premature ovulation and maintain oocyte yields by delaying the administration of MPA until the midcycle (referred to as fPPOS), similar to GnRH antagonist injections.
Investigating the factors that influence Chinese undergraduate students' sustained use of open source communities.
PLoS One
December 2024
Department of Curriculum & Instructional Technology, Faculty of Education, Universiti Malaya, Kuala Lumpur, Malaysia.
The progress of open source technology is inseparable from cultivating open source talents in universities. The combination of open source communities and university education can cultivate students' practical innovation abilities. Currently, we are facing problems such as the shortage of open source talents and the sustained use of open source technologies by open source talents.
View Article and Find Full Text PDFPsychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review.
Epilepsia Open
December 2024
University of Florence, Florence, Italy.
People with epilepsy (PWE) are at higher risk of psychiatric disorders (PD), disability, and reduced quality of life than the general population, especially in childhood and adolescence and when seizures originate from the temporal lobe. Temporal Lobe Epilepsy (TLE) is the most common type of focal epilepsy and can be due to structural abnormalities, or non-lesional causes, such as genetic variants. The prevalence of PD is approximately 20%-30% in people with epilepsy in general, and from 40% up to 80% in people with TLE.
View Article and Find Full Text PDFIntegrated Profiling of Extracellular Vesicle microRNA Impact on Trabecular Meshwork mRNA Expression: Insights From Microarray Analysis.
Invest Ophthalmol Vis Sci
December 2024
Department of Software and Information Systems Engineering, Faculty of Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Purpose: Extracellular vesicles (EVs) secreted by non-pigmented ciliary epithelial (NPCE) cells under oxidative stress may contribute to primary open-angle glaucoma (POAG) pathogenesis by altering gene expression in human trabecular meshwork (HTM) cells. This study investigated the impact of microRNAs (miRNAs) carried by NPCE-derived EVs on HTM cell gene expression under oxidative stress conditions.
Methods: NPCE cells were exposed to oxidative stress, and EVs were isolated from control and stressed cells.
Nursing Students' Experiences About Clinical Practice Tutoring: A Cross-Sectional Observational Study.
Nurs Rep
December 2024
Nursing Department, Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, 41009 Seville, Spain.
Unlabelled: Nursing students' experiences about clinical practice tutoring in a public university from southern Spain and at its two attached educational centres were analysed.
Methods: A cross-sectional observational study was carried out. The population was comprised of nursing students attending their fourth year of university during the 2023/2024 academic period, with a final sample of 179 subjects.
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