AI Article Synopsis
- The c-MPL-TPO axis plays a key role in hematopoiesis by activating important signaling pathways like JAK/STAT, MAPK/ERK, and PIK3/AKT.
- This research emphasizes the effects of c-MPL mutations on blood cell formation and highlights c-MPL's involvement in diseases beyond blood disorders, such as Unstable Angina and DNA damage repair.
- The study suggests the potential of c-MPL as a therapeutic target and biomarker for cancer-related issues, advocating for further exploration of its isoforms for future gene-therapy applications.
Article Abstract
The c-MPL-TPO axis regulates hematopoiesis by activating various signalling cascades, including JAK/STAT, MAPK/ERK, and PIK3/AKT. Here, we have summarized how TPO is regulated by c-MPL and, how mutations in the c-MPL regulate hematopoiesis. We also focus on its non-hematological regulatory role in diseases like Unstable Angina and pathways like DNA damage repair, skeletal homeostasis, & apoptotic regulation of neurons/HSCs at the embryonic state. We discuss the therapeutic efficiency of c-MPL and, its potential to be developed as a bio-marker for detecting metastasis and development of chemo-resistance in various cancers, justifying the multifaceted nature of c-MPL. We have also highlighted the importance of c-MPL isoforms and their stoichiometry in controlling the HSC quiescent and proliferative state. The regulation of the ratio of different isoforms through gene-therapy can open future therapeutic avenues. A systematic understanding of c-MPL-isoforms would undoubtedly take one step closer to facilitating c-MPL from basic-research towards translational medicine.
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| http://dx.doi.org/10.1007/s13402-024-00988-w | DOI Listing |
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