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Euphorbium compositum SN improves the innate defenses of the airway mucosal barrier network during rhinovirus infection.
Respir Res
November 2024
Center for Inflammation and Lung Research, Lewis Katz Medical School, Temple University, Philadelphia, PA, 19140, USA.
Background: Rhinoviruses (RV) are the major cause of common colds in healthy individuals and are associated with acute exacerbations in patients with chronic lung diseases. Yet, no vaccines or effective treatment against RV are available. This study investigated the effect of Euphorbium compositum SN (ECSN6), a multicomponent, multitarget medication made from natural ingredients, on the mucosal barrier network during RV infection.
View Article and Find Full Text PDFMagnetic nanobead assisted the dual targets driven fluorescent biosensor based on SPEXPAR and MNAzyme for the olfactory marker protein detection.
Mater Today Bio
December 2024
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Fig. 1: Schematic illustration of the principle of the Dual targets driven SPEXPAR assisted MNAzyme (D-S-M) fluorescent biosensor for olfactory marker protein (OMP) detection. A.
View Article and Find Full Text PDFHigh-Resolution Terahertz Spectroscopy for Medical Diagnostics.
J Biophotonics
October 2024
Terahertz Spectrometry Department, Institute for Physics of Microstructures of RAS, Nizhny Novgorod, Nizhny Novgorod Region, Russia.
Article Synopsis
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A new multicomponent nasal spray for managing children with recurrent upper respiratory infections.
Minerva Pediatr (Torino)
December 2024
Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy -
We present an efficient approach for synthesizing cationic poly(ethylene imine) derivatives using the multicomponent split-Ugi reaction to rapidly create a library of complex functional ionizable lipopolymers. We synthesized a diverse library of 155 polymers, formulated them into polyplexes to establish structure-activity relationships crucial for endosomal escape and efficient transfection. After discovering a lead structure, lipopolymer-lipid hybrid nanoparticles are introduced to preferentially deliver to and elicit effective mRNA transfection in lung endothelium and immune cells, including T cells with low toxicity.
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