Post-selection inference in regression models for group testing data.

Biometrics

Department of Statistics, University of South Carolina, Columbia, SC 29208, United States of America.

Published: July 2024

AI Article Synopsis

  • Developed a methodology for logistic regression that allows for valid inference when responses are partly observed due to error-prone outcomes.
  • Utilized the expectation-maximization algorithm with LASSO penalization to accurately estimate important covariates while addressing missing response data.
  • Demonstrated through simulations that this method of post-selection inference is more reliable compared to traditional naive methods that do not account for variable selection.

Article Abstract

We develop a methodology for valid inference after variable selection in logistic regression when the responses are partially observed, that is, when one observes a set of error-prone testing outcomes instead of the true values of the responses. Aiming at selecting important covariates while accounting for missing information in the response data, we apply the expectation-maximization algorithm to compute maximum likelihood estimators subject to LASSO penalization. Subsequent to variable selection, we make inferences on the selected covariate effects by extending post-selection inference methodology based on the polyhedral lemma. Empirical evidence from our extensive simulation study suggests that our post-selection inference results are more reliable than those from naive inference methods that use the same data to perform variable selection and inference without adjusting for variable selection.

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http://dx.doi.org/10.1093/biomtc/ujae101DOI Listing

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