AI Article Synopsis
- The study focuses on adiponectin (ADN) levels in children aged 9-12 with and without obesity, specifically in those with type 1 diabetes (DMT1).
- ADN levels were found to be higher in DMT1 patients than in healthy controls, but were lower in obese individuals compared to non-obese ones in both groups.
- The findings suggest that reduced ADN levels in obese diabetic or non-diabetic subjects may indicate insulin resistance and mechanisms that impact weight maintenance.
Article Abstract
Objectives: Adiponectin (ADN) is related to insulin resistance and cardiovascular disorders risks. It is negatively controlled in obese cases among diabetes mellitus type 1 (DMT1) patients. The current study evaluates ADN levels in early-aged children 9-12 years old of obese and non-obese cases (DMT1).
Methods: A cross-sectional study among children aged 9-11 years old, was conducted during the year 2023 within two groups. First was a diabetic children DMT1 group excluding diabetic cases with complications. Second was a healthy children's control group. Two groups were subdivided into two subgroups, obese and non-obese ( = 6 for each subgroup). ADN concentrations were measured in DMT1 cases related to weight and body mass index among treated and non-treated with insulin-therapy compared to diabetic rats. Adult albino male rats enrolled in a control group, non-treated diabetic, and insulin-treated diabetic rats. Statistical analysis-based measuring means and standard deviation for each group and comparing them with the student t-test.
Results: Significantly increased plasma AND levels were detected in DMT1 patients compared to non-diabetic cases ( < 0.001). AND levels were decreased in obese rather than non-obese cases of control or diabetic cases ( < 0.001). Data shows significantly increased plasma AND levels in experimental rats, induced with diabetes (with or without insulin treatment) compared to the control group ( < 0.001).
Conclusion: Plasma ADN levels were significantly reduced in obese subjects' diabetics or non-diabetics. It may refer to insulin resistance or mechanisms that prevent further weight gain by decreasing insulin sensitivity and increasing energy expenditure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393390 | PMC |
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