The purpose of this commentary is to describe combinatory play as a practice for elevating creativity and well-being among public health professionals. Albert Einstein introduced combinatory play in a letter to a colleague, and, in this commentary, we define it as engagement in an intrinsically enjoyable, cognitively stimulating artistic activity that is distinct from one's job tasks and conducive to connecting ideas toward insight and creative problem-solving. Combinatory play aligns with empirical and experiential evidence demonstrating connections between art and science. We present combinatory play in the context of research on creativity and well-being, including the growing issue of work-related stress among public health professionals. To provide an example of combinatory play, we recount how Robert Frost's poem "Mending Wall" inspired email blackout periods and an intervention for health researchers. Finally, we outline concrete strategies for public health professionals to integrate combinatory play into their lives. Overall, combinatory play is a promising practice for catalyzing novel solutions to public health issues while fueling the well-being of public health professionals themselves.
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http://dx.doi.org/10.1016/j.puhip.2024.100546 | DOI Listing |
Int Urol Nephrol
December 2024
Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Secondary hyperparathyroidism (SHPT) is one of the most common complications of chronic kidney disease (CKD). Vitamin D levels begin to decrease in the early stages of CKD, and these vitamin D-related changes play a central role in the occurrence and development of SHPT. Vitamin D-based drugs, which inhibit parathyroid hormone secretion either directly or indirectly, are commonly used to treat SHPT.
View Article and Find Full Text PDFJ Mater Chem B
December 2024
Department of Biological Sciences and Engineering, Indian Institute of Technology Palakkad, Palakkad, Kerala, 678 557, India.
MXenes are a class of two-dimensional nanomaterials with the general formula MXT, where M denotes a transition metal, X denotes either carbon or nitrogen and T refers to surface terminations, such as -OH, -O, -F or -Cl. The unique properties of MXenes, including their tunable surface chemistry and high surface area-to-volume ratio, make them promising candidates for various biomedical applications, such as targeted drug delivery, photothermal therapy and so on. Among the family of MXenes, titanium (Ti)-based MXenes, especially TiCT, have been extensively explored for biomedical applications.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Institute of Microbiology, Friedrich Schiller University, 07743 Jena, Germany.
Small RNAs (sRNAs) play a crucial role in modulating target gene expression through short base-pairing interactions and serve as integral components of many stress response pathways and regulatory circuits in bacteria. Transcriptome analyses have facilitated the annotation of dozens of sRNA candidates in the ubiquitous environmental model bacterium Caulobacter crescentus, but their physiological functions have not been systematically investigated so far. To address this gap, we have established CauloSOEP, a multi-copy plasmid library of C.
View Article and Find Full Text PDFAntimicrob Agents Chemother
December 2024
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, Republic of Korea.
Bacterial efflux pumps play important roles in the antibiotic resistance and excretion of virulence factors. We previously characterized that TolCV1, a component of efflux pumps, plays critical roles in resistance to antibiotics and bile and also RtxA1 toxin secretion of . In this context, we speculated that TolCV1 blockers would have a dual effect of enhancing susceptibility to antibiotics and suppressing virulence of .
View Article and Find Full Text PDFFundam Res
July 2024
Research Center for Mathematics and Interdisciplinary Sciences, Frontiers Science Center for Nonlinear Expectations (Ministry of Education), Shandong University, Shandong 266000, China.
DNA barcodes, short and unique DNA sequences, play a crucial role in sample identification when processing many samples simultaneously, which helps reduce experimental costs. Nevertheless, the low quality of long-read sequencing makes it difficult to identify barcodes accurately, which poses significant challenges for the design of barcodes for large numbers of samples in a single sequencing run. Here, we present a comprehensive study of the generation of barcodes and develop a tool, PRO, that can be used for selecting optimal barcode sets and demultiplexing.
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