AI Article Synopsis
- Cangfu Daotan decoction is a traditional Chinese medicine that shows promise for treating polycystic ovarian syndrome (PCOS) in humans when used alongside Diane-35, a common medication for the condition.* -
- A review of 25 randomized controlled trials showed that combining Cangfu Daotan with Diane-35 significantly improved response, pregnancy, and ovulation rates, and reduced various hormone levels and body mass index, while also addressing symptoms of excess androgen.* -
- The findings indicate that this herbal treatment is generally safe with mild side effects, but the impact on follicle-stimulating hormone levels is unclear and the studies had some bias and variability in quality.*
Article Abstract
Objective: Cangfu Daotan decoction is a classic traditional Chinese medicine formula that has been found to be beneficial for treating polycystic ovarian syndrome (PCOS) in animal models. This systematic review aimed to assess the efficacy and safety of Cangfu Daotan decoction as an adjuvant treatment to Diane-35 for PCOS in humans.
Methods: Seven electronic databases were searched up to June 22, 2024, to identify randomized controlled trials (RCTs) that evaluated Cangfu Daotan decoction combined with Diane-35 versus Diane-35 alone for the treatment of PCOS. The effects of individual RCTs were combined via meta-analysis and were measured as relative risks (RRs) or weighted mean differences (WMDs).
Results: Twenty-five RCTs with a moderate to high risk of bias were included, involving 1845 patients with PCOS. Meta-analyses indicated that compared with Diane-35 alone, the combination of Diane-35 and Cangfu Daotan decoction significantly improved the response rate (RR 1.19, 95 % confidence interval [CI] 1.14 to 1.24), pregnancy rate (RR 1.57, 95 % CI 1.18 to 2.09), ovulation rate (RR 1.22, 95 % CI 1.11 to 1.35), and ovarian volume (WMD -1.43 cm, 95 % CI -2.46 to -0.39). Cangfu Daotan decoction also significantly reduced the luteinizing hormone (LH) level, LH:FSH ratio, testosterone level, prolactin level, body mass index (BMI) and hirsutism and acne scores but had no significant effect on the follicle-stimulating hormone (FSH) level. All adverse events were mild and not related to Cangfu Daotan decoction treatment.
Conclusions: The findings suggest that Cangfu Daotan decoction, as an adjuvant therapy to Diane-35 for the treatment of PCOS, can reduce multiple sex hormone levels and BMI, relieve hyperandrogenism signs, and ultimately improve pregnancy outcomes, with good safety. The effect of Cangfu Daotan decoction on FSH remains uncertain. Due to limitations of risk of bias and heterogeneity, the quality of evidence was rated as moderate to very low.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401213 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e36959 | DOI Listing |
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