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| http://dx.doi.org/10.1093/ckj/sfae262 | DOI Listing |
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Identification of three distinct cell populations for urate excretion in human kidneys.
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Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan; V-iCliniX Laboratory, Nara Medical University, Kashihara, Nara, Japan. Electronic address:
In humans, uric acid is an end-product of purine metabolism. Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal urate transporters.
View Article and Find Full Text PDFFrom Laggard To Leader: Why Health Care In The United States Is Failing, And How To Fix It.
Health Aff (Millwood)
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Len M. Nichols, Urban Institute, Washington, D.C.
Health care in the United States is among the most technologically advanced in the world, but it is largely failing to meet the needs of the nation. The US can claim international excellence in important areas of care, such as cancer treatment, and it leads the world in biomedical innovation and building a well-prepared and dedicated clinical workforce. The Affordable Care Act was a major step forward in expanding access to health care in the US.
View Article and Find Full Text PDFSocial Health and Serious Mental Illness-A Step Forward?
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ESRC Centre for Society and Mental Health, King's College London, London, United Kingdom.
A generalizable normative deep autoencoder for brain morphological anomaly detection: application to the multi-site StratiBip dataset on bipolar disorder in an external validation framework.
Artif Intell Med
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Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
The heterogeneity of psychiatric disorders makes researching disorder-specific neurobiological markers an ill-posed problem. Here, we face the need for disease stratification models by presenting a generalizable multivariate normative modelling framework for characterizing brain morphology, applied to bipolar disorder (BD). We used deep autoencoders in an anomaly detection framework, combined for the first time with a confounder removal step that integrates training and external validation.
View Article and Find Full Text PDFComprehensive analysis of 111 Pleuronectiformes mitochondrial genomes: insights into structure, conservation, variation and evolution.
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Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Background: Pleuronectiformes, also known as flatfish, are important model and economic animals. However, a comprehensive genome survey of their important organelles, mitochondria, has been limited. Therefore, we aim to analyze the genomic structure, codon preference, nucleotide diversity, selective pressure and repeat sequences, as well as reconstruct the phylogenetic relationship using the mitochondrial genomes of 111 flatfish species.
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