AI Article Synopsis
- Some studies suggest an increase in sunburns and cutaneous melanoma (CM) risk, but a direct cause-and-effect relationship has not been proven.
- This study utilized a two-sample Mendelian randomization approach to investigate the potential causal link between sunburn history and CM using extensive genome-wide data.
- The findings indicate a causal association, suggesting that a history of sunburn increases the risk of CM, particularly pointing to shared genetic factors among Caucasian, European, or British populations.
Article Abstract
Background: Some studies have reported that sunburns and cutaneous melanoma (CM) risk is increasing, but a clear causal link has yet to be established.
Methods: This current study conducted a two-sample Mendelian randomization (MR) approach to clarify the association and causality between sunburn history and CM using large-scale genome-wide association study data.
Results: The inverse-variance weighted method result showed that sunburn might be associated with the risk of CM increasing (p = 2.21 × 10, OR = 1.034, 95% CI= 1.027-1.041), causally. The MR-Egger regression, weighted median method, simple mode method, and weighted mode method results showed similar results.
Conclusion: This study offers evidence of sunburn history and increased risk of CM, and it shows that there might be common genetic basics regarding sunburns and CM susceptibility in Caucasian, European, or British ethnic groups.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392754 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1393833 | DOI Listing |
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