AI Article Synopsis
- * A study tested a "biodegradable neuroprotective stent" made from magnesium, which releases magnesium and hydrogen locally to help protect the brain from injury during the recovery phase.
- * Results showed that magnesium improved neuron survival in lab tests and protected against various harmful effects in a rat model, suggesting that magnesium-based implants could be a promising treatment for brain ischemia.
Article Abstract
Most acute ischemic stroke patients with large vessel occlusion require stent implantation for complete recanalization. Yet, due to ischemia-reperfusion injury, over half of these patients still experience poor prognoses. Thus, neuroprotective treatment is imperative to alleviate the ischemic brain injury, and a proof-of-concept study was conducted on "biodegradable neuroprotective stent". This concept is premised on the hypothesis that locally released Mg/H from Mg metal within the bloodstream could offer synergistic neuroprotection against reperfusion injury in distant cerebral ischemic tissues. Initially, the study evaluated pure Mg's neuroactive potential using oxygen-glucose deprivation/reoxygenation (OGD/R) injured neuron cells. Subsequently, a pure Mg wire was implanted into the common carotid artery of the transient middle cerebral artery occlusion (MCAO) rat model to simulate human brain ischemia/reperfusion injury. analyses revealed that pure Mg extract aided mouse hippocampal neuronal cell (HT-22) in defending against OGD/R injury. Additionally, the protective effects of the Mg wire on behavioral abnormalities, neural injury, blood-brain barrier disruption, and cerebral blood flow reduction in MCAO rats were verified. Conclusively, Mg-based biodegradable neuroprotective implants could serve as an effective local Mg/H delivery system for treating distant cerebral ischemic diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402188 | PMC |
| http://dx.doi.org/10.1016/j.bioactmat.2024.08.019 | DOI Listing |
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