AI Article Synopsis

  • - Neutrophilic figurate erythema (NFE) is a rare skin condition that resembles erythema annulare centrifugum (EAC) but is characterized by a neutrophil-dominated inflammatory response in the skin.
  • - A case study of a 32-year-old military male showed a chronic skin rash that started five years ago, resistant to multiple antifungal treatments, with no identifiable triggers or improvement post-deployment.
  • - Diagnosis of NFE can be challenging due to its rarity, with only 15 known cases, and it may require specific treatment focusing on anti-neutrophil therapy rather than standard antifungal options.

Article Abstract

Neutrophilic figurate erythema (NFE) is a rarely reported figurate erythema that clinically presents similarly to erythema annulare centrifugum (EAC) with neutrophil-predominant perivascular and interstitial infiltrate in the dermis on histopathology. We present the case of a 32-year-old active-duty military male who presented with a chronic treatment-resistant skin rash. The rash began on his thighs five years previously and was treated with topical and oral antifungals repeatedly without improvement. The patient was deployed overseas during the rash onset, but the rash persisted upon his return stateside. No triggers were identified. His persistent skin eruption consisted of erythematous polycyclic annular plaques with a "trailing edge" scale. Histologic examination revealed perivascular neutrophils and perivascular and interstitial eosinophils without signs of vasculitis or infection. With only 15 reported cases, it can be difficult to recognize leading to long delays in diagnosis and treatment. Despite having a clinical course similar to EAC, NFE may require anti-neutrophil therapy to resolve completely.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401626PMC
http://dx.doi.org/10.7759/cureus.66920DOI Listing

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