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Advances in the awareness of tuberculosis-associated chronic obstructive pulmonary disease.
Chin Med J Pulm Crit Care Med
December 2024
Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Center for Chronic Airway Diseases, Peking University Health Science Center, Peking University, Beijing 100191, China.
Tuberculosis (TB) significantly increases the risk of developing chronic obstructive pulmonary disease (COPD), positioning TB-associated COPD (TB-COPD) as a distinct category within the spectrum of respiratory diseases prevalent, especially in low- and middle-income countries. This condition results from the body's immune response to TB, leading to prolonged inflammation and consequent persistent lung damage. Diagnostic approaches, particularly post-bronchodilator spirometry, are vital for identifying airflow obstruction and confirming TB-COPD.
View Article and Find Full Text PDFType and physical intensity of occupations at pulmonary TB diagnosis.
IJTLD Open
January 2025
Respiratory Epidemiology & Clinical Research Unit, Centre for Outcomes Research & Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Background: Pulmonary TB (PTB) predominantly affects individuals of working age. We sought to characterise the occupations of people newly diagnosed with PTB in Karachi, Pakistan, by type and physical intensity.
Design/methods: We did a secondary analysis of data from a study evaluating the diagnostic accuracy of artificial intelligence-based chest X-ray (CXR) analysis software, where individuals had been evaluated for active PTB using sputum cultures and had provided information on occupation.
The Incidence, Risk Factors, and Predictive Model of Obstructive Disease in Post-Tuberculosis Patients.
Int J Chron Obstruct Pulmon Dis
November 2024
Department of Respiratory, Unit Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, Urumqi, 830000, People's Republic of China.
Article Synopsis
- The study assessed the incidence and risk factors of tuberculosis-associated obstructive pulmonary disease (TOPD) in patients with untreated pulmonary tuberculosis (PTB) in Xinjiang, China, over one year.
- It found that 43.4% of the 159 patients developed TOPD, with significant risk factors including age, body mass index, ESR, and symptom duration identified through multivariate analysis.
- A predictive model was established with a sensitivity of 89% and specificity of 83%, aimed at improving early detection and management of TOPD in PTB patients for better health outcomes.
Identification of Post-Tuberculosis Lung Function Impairment Early during the Course of Treatment.
Am J Trop Med Hyg
January 2025
Vanderbilt Institute of Global Health, Vanderbilt University, Nashville, Tennessee.
Tuberculosis (TB) is a leading cause of morbidity and mortality and an important contributory factor to chronic lung disease. TB-associated permanent lung damage manifests with varying levels of respiratory disability long after TB has been successfully treated, which is a condition known as post-TB lung disease (PTLD). This study assessed whether lung function impairment associated with PTLD occurs early during TB treatment.
View Article and Find Full Text PDFHIV co-infection increases the risk of post-tuberculosis mortality among persons who initiated treatment for drug-resistant tuberculosis.
Sci Rep
October 2024
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Article Synopsis
- * Out of 1,032 participants, 3.3% died during treatment and 8.7% after, with a median death time of 21 months post-TB treatment, particularly within the first 3 years.
- * Those with HIV co-infection had a significantly higher risk of post-TB mortality (almost four times higher) compared to those without HIV, highlighting the need for better care for TB patients with comorbidities.
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