AI Article Synopsis
- - Vanishing lung syndrome (VLS) is a rare condition marked by large emphysematous bullae that lead to lung compression, causing breathing difficulties and reduced physical capacity, with potential for sudden symptom worsening from pneumothorax.
- - The text discusses three pediatric cases of VLS linked to tuberculosis (TB), highlighting that cases of VLS from TB are scarce in literature and that these cases exhibited faster disease progression and extensive bilateral bullae.
- - Notably, one patient did not receive isoniazid, a drug often associated with VLS, raising questions about the factors contributing to this condition and hinting at potential sex differences, as all three patients were female.
Article Abstract
Vanishing lung syndrome (VLS) or idiopathic giant bullous disease is a rare condition characterized by giant emphysematous bullae, classically presenting as a slowly enlarging bulla that compresses normal lung parenchyma and causes mediastinal shift, leading to increasing dyspnea and reduced exercise tolerance. Intermittent sudden worsening of symptoms may be seen because of secondary pneumothorax due to rupture of these bullae. Here we present three cases of vanishing lung syndrome in children due to tuberculosis (TB). Reports on VLS due to TB are bare minimum. In contrast to most of the published case reports, our cases had a moderate to rapid progression, bilateral extensive bullae and isoniazid which has been traditionally thought to be the causative factor was not used in one of our patients. All three are female patients arising new horizons of research regarding whether there is any sex predominance.
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| http://dx.doi.org/10.1016/j.ijtb.2024.06.009 | DOI Listing |
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