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Exploring the LET dependence of DNA DSB repair kinetics using the DR DNA database. | LitMetric

Exploring the LET dependence of DNA DSB repair kinetics using the DR DNA database.

J Radiat Res

Department of Radiation Oncology, Mayo Clinic, 4450 San Pablo Rd S, Jacksonville, FL 32224, USA.

Published: September 2024

AI Article Synopsis

Article Abstract

The repair of DNA double-strand breaks is a crucial yet delicate process which is affected by a multitude of factors. In this study, our goal is to analyse the influence of the linear energy transfer (LET) on the DNA repair kinetics. By utilizing the database of repair of DNA and aggregating the results of 84 experiments, we conduct various model fits to evaluate and compare different hypothesis regarding the effect of LET on the rejoining of DNA ends. Despite the considerable research efforts dedicated to this topic over the past decades, our findings underscore the complexity of the relationship between LET and DNA repair kinetics. This study leverages big data analysis to capture overall trends that single experimental studies might miss, providing a valuable model for understanding how radiation quality impacts DNA damage and subsequent biological effects. Our results highlight the gaps in our current understanding, emphasizing the pressing need for further investigation into this phenomenon.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420981PMC
http://dx.doi.org/10.1093/jrr/rrae071DOI Listing

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