AI Article Synopsis
Article Abstract
This study aimed to evaluate the repeated oral administration of α-terpineol in juvenile Wistar rats over a 70-day period. The objective was to assess the potential systemic and reproductive toxicity of α-terpineol when administered by gavage at doses of 75, 150, and 300 mg/kg/day to juvenile Wistar rats for 70 days from postnatal day 24. The control group received corn oil for 70 days. During the study, various parameters were evaluated, including clinical signs, body weight, food intake, neurobehavioral observations, haematology, serum biochemistry, organ weights, steroidogenic gene expression, and histopathological examination. No toxicity-related changes were observed in body weight, food intake, neurobehavioral observations, or steroidogenic gene expression. However, sperm evaluation revealed a complete absence of sperm and delayed sexual maturation. Total cholesterol was significantly elevated in both sexes, and serum testosterone was reduced at the 150 and 300 mg/kg doses. Microscopic examination showed severe pathological changes in the testes, epididymis, liver, and kidneys of both males and females. After the 14-day recovery period, total cholesterol levels returned to the normal range, but no recovery was observed in the other organs. The no-observed-adverse-effect level was 75 mg/kg/day for male rats based on the histopathological findings in the testes, liver, and kidneys, and for female rats based on the kidney and liver histopathology.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.taap.2024.117106 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Advances in the Pathophysiology and Drug Discovery of Novel Therapeutics for Attention-Deficit/hyperactivity Disorder].
Yakugaku Zasshi
December 2024
Department of Pharmacology, Faculty of Pharmaceutical Science, Health Sciences University of Hokkaido.
Article Synopsis
- ADHD is a neurodevelopmental disorder marked by inattention, hyperactivity, and impulsivity, typically treated with psychostimulants like methylphenidate, which have significant side effects and addiction risks.
- * The study used juvenile stroke-prone spontaneously hypertensive rats (SHRSP/Ezo) to explore D-serine levels and NMDA receptor dysfunction in relation to ADHD, finding a lower D-serine/total serine ratio in these rats compared to control rats.
- * Inhibiting DAAO in the mPFC improved the D-serine levels and reduced ADHD-like behaviors in SHRSP/Ezo, suggesting that D-serine metabolism may play a key role in ADHD's pathogenesis and pointing towards potential new treatments
To Play or Not to Play? Effects of Playmate Familiarity and Social Isolation on Social Play Engagement in Three Laboratory Rat Strains.
bioRxiv
November 2024
Department of Psychology, Michigan State University, East Lansing, MI 48824, USA.
Social play is a motivating and rewarding behavior displayed by juveniles of many mammalian species, including humans and rats. Social play is vital to the development of social skills. Autistic children show less social play engagement which may contribute to their impairments in social skills.
View Article and Find Full Text PDFRenal Inflammation, Oxidative Stress, and Metabolic Abnormalities During the Initial Stages of Hypertension in Spontaneously Hypertensive Rats.
Cells
October 2024
Department of Human Physiology and Pathophysiology, Collegium Medicum, University of Warmia and Mazury, Warszawska Av, 30, 10-082 Olsztyn, Poland.
Hypertension is a major cause of mortality worldwide. The kidneys play a crucial role in regulating blood pressure and fluid volume. The relationship between the kidneys and hypertension is complex, involving factors such as the renin-angiotensin system, oxidative stress, and inflammation.
View Article and Find Full Text PDFPerinatal bisphenol A exposure has an age- and dose-dependent association with thyroid allostasis adaptive response, as well as anxiogenic-depressive-like and asocial behaviors in juvenile and adult male rats.
Physiol Behav
January 2025
Zoology, Biological and Geological Sciences Department, Faculty of Education, Alexandria University, Alexandria, Egypt.
Thyroid hormones are essential for brain development, and a shortage throughout the fetal and postnatal periods can result in mood disorders. Perinatal exposure to bisphenol A (BPA) affects thyroid activity and dependent processes indirectly during pregnancy or early postnatal life. This is particularly important because it may cause changes in tissue ontogeny, increasing the risk of developing disorders later in life.
View Article and Find Full Text PDFStress enhances aggression in male rats with genetic stress hyper-reactivity.
Genes Brain Behav
October 2024
Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Article Synopsis
- - The study examined how stress influences aggression in two genetically distinct male mouse strains: the stress-hyper-reactive Wistar Kyoto More Immobile (WMI) and the control Wistar Kyoto Less Immobile (WLI), using a resident-intruder test.
- - Prior acute stress led to decreased social interactions and aggression in adult WLIs, but increased aggression in stressed adult WMIs toward both same-age and juvenile intruders, indicating a genetic predisposition to stress-induced aggression.
- - Genetic analysis revealed alterations in aggression-related genes between strains, with specific changes in the frontal cortex and amygdala of WMIs after stress, suggesting that their genetic makeup contributes to heightened aggression under stress, potentially opening pathways for future research on
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!