A comprehensive review of current treatment modalities for leptomeningeal carcinomatosis in breast cancer.

Crit Rev Oncol Hematol

Emily Couric Comprehensive Cancer Center, Division of Hematology/Oncology, University of Virginia, Charlottesville, VA, USA. Electronic address:

Published: December 2024

Leptomeningeal carcinomatosis (LC) is a metastatic complication of breast cancer that imparts a very poor prognosis and distressing neurologic symptoms in affected patients. While the incidence of LC has risen with improving survival rates for cancer patients, there remains no established treatment protocol for LC and clinical trial data comparing available therapies is limited. Here, a comprehensive literature search of the pubmed and Cochrane databases was performed. Current treatment modalities and their safety/ efficacy profiles are summarized for LC in breast cancer. Roles for emerging therapies in LC are discussed, including targeted agents, CAR-T, immune checkpoint inhibitors, CDK inhibitors and novel antibody conjugates. A treatment pathway for LC is also proposed to guide clinicians through management of this severe metastatic complication of breast cancer.

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Source
http://dx.doi.org/10.1016/j.critrevonc.2024.104513DOI Listing

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