AI Article Synopsis
- A 52-year-old male developed severe weakness and was hospitalized due to hypokalemia and rhabdomyolysis after increasing his chlorthalidone dosage from 25 mg to 50 mg daily.
- Extensive testing eliminated other potential causes of his hypokalemia, indicating it was likely due to the medication.
- The patient's condition improved significantly with potassium supplementation and stopping the chlorthalidone, highlighting the need for awareness about serious side effects of diuretics even with minor dose adjustments.
Article Abstract
Purpose: A case of hypokalemic rhabdomyolysis related to chlorthalidone use is reported CASE SUMMARY: A 52-year-old male was admitted to the hospital for acute onset generalized weakness and was found to have severe hypokalemia and rhabdomyolysis. The patient had been on chlorthalidone therapy with a dose increase from 25 mg daily to 50 mg daily 2 months prior to admission. Extensive workup ruled out neurologic, rheumatologic, and endocrinologic causes of hypokalemia. In the absence of other causes, it was determined that the patient was experiencing a severe presentation of chlorthalidone-induced hypokalemia resulting in rhabdomyolysis. The patient's rhabdomyolysis and weakness improved with aggressive potassium correction, and potassium wasting eventually resolved with discontinuation of chlorthalidone.
Conclusion: Although mild hypokalemia is a known side effect of thiazide and thiazide-like diuretics, health care providers should be aware of the possibility of severe manifestations of this adverse reaction, even at relatively small dose increases.
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| http://dx.doi.org/10.1016/j.japh.2024.102249 | DOI Listing |
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- A 52-year-old male developed severe weakness and was hospitalized due to hypokalemia and rhabdomyolysis after increasing his chlorthalidone dosage from 25 mg to 50 mg daily.
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