AI Article Synopsis
- Oral cancer is a significant global health issue, and early detection is key to better patient outcomes.
- Fructose 1,6-bisphosphate aldolase (FBA) is a glycolytic enzyme that shows promise as a prognostic marker for oral cancer, potentially impacting treatment and survival rates.
- Recent studies indicate that FBA's role in tumor metabolism may contribute to radiation resistance, suggesting that targeting FBA could lead to more personalized and effective treatment strategies.
Article Abstract
Oral cancer remains a significant global health concern and its early detection plays a crucial role in improving patient outcomes. Identifying reliable prognostic markers is essential to guide treatment decisions and enhance survival rates. Fructose 1,6-bisphosphate aldolase (FBA), a glycolytic enzyme, has emerged as a promising candidate for prognostic assessment of oral cancer. This review highlights the role of FBA in tumorigenesis, its potential utility in predicting disease progression and patient survival, and its influence on response to radiotherapy. Recent studies have suggested that dysregulated metabolic pathways involving FBA may contribute to radiation resistance in oral cancer, emphasizing the need for further exploration of FBA-targeted therapeutic strategies. Understanding the role of FBA in oral cancer pathogenesis could pave the way for the development of personalized treatment strategies, including combined radiotherapy.
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| http://dx.doi.org/10.1016/j.radonc.2024.110537 | DOI Listing |
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