AI Article Synopsis
- Chronic gastritis is marked by inflammation of the stomach lining and the study aimed to explore its clinical and pathological factors, focusing on the role of CD117 as a marker for mast cell density (MCD).
- The research was conducted in Iraqi Kurdistan involving 380 patients, analyzing various indicators of gastritis severity and using an antibody to assess CD117 levels.
- The findings showed a significant correlation between Helicobacter pylori-related gastritis and factors like age and MCD, with higher MCD in patients with severe gastritis, while those who underwent treatment exhibited a decrease in MCD, underscoring the need for early diagnosis in areas with high H. pylori rates.
Article Abstract
Introduction: Chronic gastritis is a group of conditions commonly characterized by stomach lining inflammation. The study aimed to investigate the clinical and pathological aspects that play a role in its development. Additionally, the study examines the use of CD117 as an immunohistochemistry marker in evaluating mast cell density (MCD).
Methods: This retrospective, cross-sectional study was conducted in Iraqi Kurdistan with a sample size of 380 patients. Patient data included gastritis type, neutrophil infiltration severity, mononuclear cell infiltration within the lamina propria, intestinal metaplasia, and glandular atrophy, which were categorized and given a score. The CD117 level was identified using an anti-human rabbit polyclonal antibody.
Results: A statistically significant association was revealed between Helicobacter pylori-mediated gastritis and non-specific gastritis with age, activity, H. pylori and MCD, dysplasia, and malignancy. Meanwhile, no association was found with gender, inflammatory infiltrate, intestinal metaplasia, and glandular atrophy. C-Kit exhibited a marked increase in MCD in patients with H. pylori-mediated gastritis, intestinal metaplasia, atrophy, and gastric carcinoma. However, a significant decrease in MCD was observed on repeating endoscopy evaluations for patients after treatment.
Conclusion: Regions that exhibit severe inflammation, metaplasia, atrophy, and carcinoma demonstrated an increase in MCD with H. pylori-mediated gastritis. A detailed investigation in clinical practice to screen early diagnosis and treatment needs to be performed in high H. pylori prevalence.
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