AI Article Synopsis

  • - The study aimed to compare neuronal injury biomarkers in cerebrospinal fluid of pediatric patients experiencing complex febrile seizures (CFS) versus those with infection-triggered acute encephalopathy (AE), specifically looking at the pathogenesis of AE with biphasic seizures.
  • - Researchers analyzed cerebrospinal fluid samples from 63 patients collected within 24 hours of neurological symptoms; results indicated significantly higher levels of the biomarkers S100B and GDF-15 in patients diagnosed with AESD and AE, respectively.
  • - The findings suggest that elevated S100B levels indicate active astrocyte involvement in AESD pathology, while increased GDF-15 points to a stronger defense response linked to more severe neurological injuries in infection-trigger

Article Abstract

Objective: This study aimed to measure and compare cerebrospinal fluid neuronal injury biomarkers in the acute phase of complex febrile seizure (CFS) and infection-triggered acute encephalopathy (AE). Furthermore, we determined the pathogenesis of AE with biphasic seizures and late reduced diffusion (AESD).

Methods: Pediatric patients with febrile status epilepticus who visited Hyogo Prefectural Kobe Children's Hospital from November 1, 2016, to December 31, 2022, and whose cerebrospinal fluid samples were collected within 24 h of neurological symptom onset were included. Patients were classified as having CFS or infection-triggered AE according to their definitions. Patients with AE were further categorized into AESD or unclassified AE. Cerebrospinal fluid biomarkers (neuron-specific enolase, growth differentiation factor 15 [GDF-15], S100 calcium-binding protein B [S100B], glial fibrillary acidic protein, and tau protein were measured and compared among the groups.

Results: Total of 63 patients (45 with CFS and 18 with AE) were included. Among the AE patients, nine were classified as having AESD and nine as having unclassified AE. S100B levels were significantly higher in patients with AESD than in patients with CFS (485 pg/ml vs. 175.3 pg/ml) and were even higher in patients with AESD and neurological sequelae (702.4 pg/ml). GDF-15 levels were significantly elevated in patients with AE compared to patients with CFS (85.8 pg/ml vs. 23.6 pg/ml).

Conclusions: The elevation of S100B suggests that activated astrocytes may be closely associated with the early pathology of AESD. Elevated GDF-15 levels in infection-triggered AE suggest the activation of defense mechanisms caused by stronger neurological injury.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2024.123238DOI Listing

Publication Analysis

Top Keywords

cerebrospinal fluid
16
patients cfs
12
patients
10
fluid neuronal
8
neuronal injury
8
injury biomarkers
8
infection-triggered acute
8
acute encephalopathy
8
complex febrile
8
cfs infection-triggered
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!