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In the search for new gold metalloantibiotics: In vitro evaluation of Au(III) (C^S)-cyclometallated complexes. | LitMetric

In the search for new gold metalloantibiotics: In vitro evaluation of Au(III) (C^S)-cyclometallated complexes.

J Inorg Biochem

Department of Organic and Inorganic Chemistry, University of Oviedo, Instituto Universitario de Química Organometálica Enrique Moles, C/ Julián Clavería 8, 33006 Oviedo, Spain. Electronic address:

Published: January 2025

AI Article Synopsis

Article Abstract

A series of (C^S)-cyclometallated Au(III) cationic complexes of general formula [Au(dppta)(dtc)], [Au(dppta)(azmtd)] and [Au(dppta)(azc)Cl] (dppta = N,N-diisopropyl-P,P-diphenylphosphinothioic amide-κC,S; dtc = dithiocarbamate-κS,S'; azc = azolium-2-dithiocarboxylate-κS; azmdt = azol(in)ium-2-(methoxy)methanedithiol-κS,S') were synthetized and tested against a panel of bacterial strains belonging to different Gram-positive and Gram-negative species of the ESKAPE group of pathogens. Among the tested compounds, complex 4c had the higher Therapeutic Index (TI) against multidrug resistant strains of S. aureus, S. epidermidis and A. baumannii, showing a more favourable cytotoxicity profile than the reference gold metalloantibiotic Auranofin. © 2024 xxxxxxxx. Hosting by Elsevier B.V. All rights reserved.

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http://dx.doi.org/10.1016/j.jinorgbio.2024.112735DOI Listing

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