AI Article Synopsis
- The study explored how aging affects the histone variant H3.3 in the tibialis anterior muscle of mice, finding that H3.3 levels significantly increase with age and correlate with the repressive marker H3K27me3.
- Acute exercise enhanced gene expression in younger (8-week-old) mice but did not have the same effect in older (53-week-old) mice, who showed increased H3.3 and H3K27me3 levels at rest rather than in response to exercise.
- Although H3.3 accumulation in older mice is linked to repressive chromatin formation, it also seems to improve motor function when H3.3 is artificially expressed in younger mice, indicating
Article Abstract
The present study aimed to investigate age-related changes in histone variant H3.3 and its role in the aging process of mouse tibialis anterior muscle. H3.3 level significantly increased with age and correlated with H3K27me3 level. Acute exercise successfully upregulated the target gene expression in 8-wk-old mice, whereas no upregulation was noted in 53-wk-old mice. H3K27me3 level was increased at these loci in response to acute exercise in 8-wk-old mice. However, in 53-wk-old mice, H3.3 and H3K27me3 levels were increased at rest and were not affected by acute exercise. Furthermore, forced H3.3 expression in the skeletal muscle of 8-wk-old mice led to a gradual improvement in motor function. The results suggest that age-related H3.3 accumulation induces the formation of repressive chromatin in the mouse tibialis anterior muscle. However, H3.3 accumulation also appears to play a positive role in enhancing skeletal muscle function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401410 | PMC |
| http://dx.doi.org/10.1186/s12576-024-00935-2 | DOI Listing |
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