AI Article Synopsis
- The paper discusses the method of chemical exchange saturation transfer (CEST) and how it uses Z-spectra for evaluating different contributions to the CEST signal.
- It introduces a new R-line-fit method for quantitatively separating the CEST effects based on specific parameters like solute concentration and exchange rates.
- The findings include successful R imaging of various molecules (Amide, Guanidino, NOE, and MT) to better understand how CEST effects depend on exchange rates and other parameters.
Article Abstract
The process of chemical exchange saturation transfer (CEST) is quantified by evaluating a Z-spectra, where CEST signal quantification and Z-spectra fitting have been widely used to distinguish the contributions from multiple origins. Based on the exchange-dependent relaxation rate in the rotating frame (R), this paper introduces an additional pathway to quantitative separation of CEST effect. The proposed R-line-fit method is solved by a multi-pool model and presents the advantage of only being dependent of the specific parameters (solute concentration, solute-water exchange rate, solute transverse relaxation, and irradiation power). Herein we show that both solute-water exchange rate and solute concentration monotonously vary with R for Amide, Guanidino, NOE and MT, which has the potential to assist in solving quantitative separation of CEST effect. Furthermore, we achieve R imaging of Amide, Guanidino, NOE and MT, which may provide direct insight into the dependency of measurable CEST effects on underlying parameters such as the exchange rate and solute concentration, as well as the solute transverse relaxation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401877 | PMC |
| http://dx.doi.org/10.1038/s41598-024-72141-4 | DOI Listing |
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