AI Article Synopsis
- Senescence acts as a protective mechanism against tumor growth, but cancer cells often lose important components like p16INK4A that promote this state.
- Some tumors display both signs of rapid growth and markers typical of senescence, creating a complex situation that poses challenges for accurate classification.
- The text examines the outlook for identifying these Sen-Mark+ cells and discusses potential therapeutic approaches that could utilize the senescence process in cancer treatment.
Article Abstract
Senescence is an anti-tumour mechanism and hallmark of cancer. Loss or mutation of key senescence effectors, such as p16INK4A, are frequently observed in cancer. Intriguingly, some human tumours are both proliferative and senescent-marker positive (Sen-Mark+). Here, we explore this paradox, focusing on the prognostic consequences and the current challenges in classifying these cells. We discuss future strategies for Sen-Mark+ cell detection together with emerging opportunities to exploit senescence for cancer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401916 | PMC |
| http://dx.doi.org/10.1038/s41514-024-00168-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The paradox of senescent-marker positive cancer cells: challenges and opportunities.
NPJ Aging
September 2024
Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Article Synopsis
- Senescence acts as a protective mechanism against tumor growth, but cancer cells often lose important components like p16INK4A that promote this state.
- Some tumors display both signs of rapid growth and markers typical of senescence, creating a complex situation that poses challenges for accurate classification.
- The text examines the outlook for identifying these Sen-Mark+ cells and discusses potential therapeutic approaches that could utilize the senescence process in cancer treatment.
Upregulation of p16INK4A in Peripheral White Blood Cells as a Novel Screening Marker for Colorectal Carcinoma.
Asian Pac J Cancer Prev
November 2022
Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Objective: Screening of colorectal cancer (CRC) is important for the early detection. CRC is relating to aging and immuno-senescence. One such senescent marker is p16INK4A expression in immune cells.
View Article and Find Full Text PDFComment on a Recent Article Titled "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts".
J Bone Miner Res
July 2021
Division of Geriatrics, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts.
J Bone Miner Res
February 2021
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Irisin is a myokine produced by skeletal muscle during exercise in both mice and humans. We previously showed that irisin treatment ameliorates immobility-induced osteoporosis and muscular atrophy in mice. Data in humans showed a positive association between irisin and bone mineral density (BMD) in athletes and a population of healthy children.
View Article and Find Full Text PDFMultiparameter flow cytometric detection and quantification of senescent cells in vitro.
Biogerontology
December 2020
Centre for Biological Engineering, School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, LE11 3TU, UK.
It has been over half a century since cellular senescence was first noted and characterized, and yet no consensus senescent marker has been reliably established. This challenge is compounded by the complexity and heterogenic phenotypes of senescent cells. This necessitates the use of multiple biomarkers to confidently characterise senescent cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!