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Bioprosthetic aortic valve degeneration (BAVD) is a significant clinical concern following both transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). The increasing use of bioprosthetic valves in aortic valve replacement in younger patients and the subsequent rise in cases of BAVD are acknowledged in this review which aims to provide a comprehensive overview of the incidence, diagnosis, predictors, and management of BAVD. Based on a thorough review of the existing literature, this article provides an updated overview of the biological mechanisms underlying valve degeneration, including calcification, structural deterioration, and inflammatory processes and addresses the various risk factors contributing to BAVD, such as patient demographics, comorbidities, and procedural variables.

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A 72-year-old man with a history of aortic valve replacement (AVR), mitral valve (MV) repair, and recent valve-in-valve transcatheter aortic valve replacement (TAVR) presented with bacteremia. Computed tomography (CT) and fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging noted a pseudoaneurysm, and he successfully underwent TAVR explant with aortic root and valve replacement.

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Despite the widespread adoption of valve-in-valve transcatheter aortic valve replacement (VIV-TAVR) for patients with failed aortic bioprosthesis, the effectiveness of this treatment for Japanese patients frequently associated with small aortic annuli remains unclear. From December-2011 to October-2022, 41 consecutive patients undergoing VIV-TAVR were enrolled in this study. The endpoints were technical success, device success, early safety, and two-year mortality according to implanted surgical valve size (small valves: 19-mm and 21-mm, n = 23; large valves: 23-mm and 25-mm, n = 18).

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Article Synopsis
  • The study investigates the factors influencing the need for permanent pacemaker (PPM) implantation after transcatheter aortic valve replacement (TAVR), a common complication following the procedure.
  • Researchers analyzed data from 2105 TAVR patients, excluding those with specific complications, to identify predictive models for PPM necessity.
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Article Synopsis
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