Flexible sensors play an important role in the field of smart devices. However, most flexible sensors suffer from poor sensing signal stability and monofunction. In this study, a multifunctional film (named PM) with dual conductive network structure was fabricated by nanocellulose crystal dispersed with silver nanoparticles and carbon nanotube. The PM film exhibited excellent conductivity (24.6 S/m) along with antimicrobial effects against Staphylococcus aureus and Escherichia coli. Furthermore, the PM sensor showed excellent electrothermal performance, reaching 133.1 °C within 50 s at 12 V, and an excellent temperature coefficient of resistance (TCR = -0.65 % °C) over a temperature range of 36-124 °C. More importantly, the PM sensor demonstrated a high strain sensitivity (GF = 1.66) and durability (320 cycles), capable of detecting minute human body movements at a strain as low as 1 %. Additionally, the PM sensor maintained a stable sensing performance even after 30 d of exposure to air. Therefore, the multifunctional integration of the PM sensor shows great potential for application in the field of flexible electronics.
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http://dx.doi.org/10.1016/j.ijbiomac.2024.135569 | DOI Listing |
Viruses
November 2024
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisbon, Portugal.
This systematic review assessed the prevalence of transmitted and acquired HIV drug resistance (HIVDR) and the associated risk factors in Mozambique. A search of the PubMed, Cochrane, B-On, and Scopus databases up to December 2023 was conducted and included 11 studies with 1118 HIV-1 pol sequences. Drug resistance mutations (DRMs) to NNRTIs were found in 13% of the drug-naive individuals and 31% of those on ART, while NRTI resistance occurred in 5% and 10%, respectively.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Physico-Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universității Street, 700115 Iasi, Romania.
Diabetes is a growing global health crisis that requires effective therapeutic strategies to optimize treatment outcomes. This study aims to address this challenge by developing and characterizing extended-release polymeric matrix tablets containing metformin hydrochloride (M-HCl), a first-line treatment for type 2 diabetes, and honokiol (HNK), a bioactive compound with potential therapeutic benefits. The objective is to enhance glycemic control and overall therapeutic outcomes through an innovative dual-drug delivery system.
View Article and Find Full Text PDFNutrients
December 2024
Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka, Koganei 184-8588, Tokyo, Japan.
Background: Lutein, a carotenoid, exhibits various biological activities such as maintaining the health of the eye, skin, heart, and bone. Recently, we found that lutein has dual roles in suppressing bone resorption and promoting bone formation. In this study, we examined the effects of lutein in a disuse-induced osteoporosis model using hindlimb-unloaded (HLU) mice.
View Article and Find Full Text PDFMicroorganisms
November 2024
State Key Laboratory for Conservation and Utilization of Bioresources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China.
Exotic plants can selectively recruit beneficial microorganisms, such as arbuscular mycorrhizal fungi (AMFs) and spp., during their invasion process to enhance growth and competitiveness by improving nutrient absorption and strengthening defense capabilities against herbivores. However, research in the context of invasive plants remains limited.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.
Background: The increasing prevalence of drug resistance in cancer therapy underscores the urgent need for novel therapeutic approaches. Dual enzyme inhibitors, targeting critical kinases such as CDK2 and TRKA, represent a promising strategy. The goal of this investigation was to design, synthesize, and evaluate a set of pyrazolo[1,5-]pyrimidine derivatives for their dual inhibition potential toward CDK2 and TRKA kinases, along with their potential antiproliferative against cancer cell lines.
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