AI Article Synopsis
- Global warming raises the likelihood of extreme heat waves, negatively impacting both humans and wildlife.
- The study uses zebrafish embryos to investigate how heat stress and certain chemicals affect their responses, finding that they can tolerate temperatures up to 37-38 °C.
- Results show that compounds like phenanthrene hinder behavioral adaptation to heat, while others like lapatinib and paclitaxel show cardiotoxic effects under heat stress, suggesting zebrafish embryos are a useful model for studying these interactions.
Article Abstract
Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as a model to analyze heat stress and effect of chemical compounds on responses to heat stress. The temperature adaptation limit of zebrafish embryos was 37 °C in behavioural test and 38 °C in cardiac test. Polyaromatic hydrocarbon phenanthrene completely blocked the behavioural adaptation to heat stress. Interestingly, the cardiotoxic effects of lapatinib, phenanthrene and paclitaxel were induced by heat stress. Taken together, our data indicates that motility and cardiac function of zebrafish embryos can be utilized as a model to analyze modulatory effects of compounds on heat stress.
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| http://dx.doi.org/10.1016/j.bbrc.2024.150682 | DOI Listing |
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