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The mechanisms of electrical neuromodulation.
J Physiol
December 2024
Center for Advancing Neurotechnological Innovation to Application - CRANIA, University Health Network, Toronto, ON, Canada.
The central and peripheral nervous systems are specialized to conduct electrical currents that underlie behaviour. When this multidimensional electrical system is disrupted by degeneration, damage, or disuse, externally applied electrical currents may act to modulate neural structures and provide therapeutic benefit. The administration of electrical stimulation can exert precise and multi-faceted effects at cellular, circuit and systems levels to restore or enhance the functionality of the central nervous system by providing an access route to target specific cells, fibres of passage, neurotransmitter systems, and/or afferent/efferent communication to enable positive changes in behaviour.
View Article and Find Full Text PDFCarbonate stringers are defined as a slab of carbonate bodies encased inside salt. In Oman, the intra-salt carbonate stringers are a very common target, especially in South Oman Salt Basin (SOSB). These stringers contain a large amount of hydrocarbon resources.
View Article and Find Full Text PDFLeveraging pre-trained machine learning models for islet quantification in type 1 diabetes.
J Pathol Inform
January 2025
Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, Intelligent Critical Care Center, College of Pharmacy, University of Florida, Orlando, FL, USA.
Human islets display a high degree of heterogeneity in terms of size, number, architecture, and endocrine cell-type compositions. An ever-increasing number of immunohistochemistry-stained whole slide images (WSIs) are available through the online pathology database of the Network for Pancreatic Organ donors with Diabetes (nPOD) program at the University of Florida (UF). We aimed to develop an enhanced machine learning-assisted WSI analysis workflow to utilize the nPOD resource for analysis of endocrine cell heterogeneity in the natural history of type 1 diabetes (T1D) in comparison to donors without diabetes.
View Article and Find Full Text PDFAnalysis of electrical activities in a functional neuron with dual memristors.
J Theor Biol
December 2024
College of Computer Science and Technology, Xi'an University of Science and Technology, Xi'an 710054, China. Electronic address:
Neuron as a charged body, it is easily disturbed by the external electromagnetic field, which changes the electrical activities of the neurons. In fact, the interference of external electric or magnetic field is the process of energy injection of neurons, the injection of energy will redistribute the field energy inside the neurons, and the redistribution of energy will change the electrical activities of the neurons. Therefore, we design a neuron model with double memristors to explore the external electromagnetic field on the regulation of neural electrical activity.
View Article and Find Full Text PDFRibose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes.
Biogerontology
December 2024
Neural Developmental Biology Lab, Department of Life Science, NIT Rourkela, Rourkela, 69008, India.
Advanced Glycation End (AGE) products are one such factor that accumulates during aging and age-related diseases. However, how exogenous AGE compounds cause aging is an area that needs to be explored. Specifically, how an organ undergoes aging and aging-related phenomena that need further investigation.
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